BP 897( 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- )

Catalog No. M23876 CAS No. 192384-87-5

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HNMR

HPLC

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Product Name

BP 897
Note

Research use only, not for human use.
Brief Description

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist.
Description

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3?μM, respectively).
In Vitro

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In Vivo

Animal Model:Male Listar hooded rats Dosage:0.05, 0.5, 1 mg/kg Administration:i.p.; 30 min before the session Result:Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.
Synonyms

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

D1|D2|D3|D4
Research Area

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Indication

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